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Pyronaridine-artesunate for treating uncomplicated Plasmodium

Pyronaridine-artesunate for treating uncomplicated Plasmodium

Researchers from LSTM have looked at the efficacy of using a novel artemisinin-based combination therapy (ACT), pyronaridine-artesunate, to treat malaria in areas where resistance to other ACTs is becoming a problem. The analysis finds it at least as effective as the currently used ACTs, if not better. The World Health Organization (WHO) recommends ACTs to ...

ERADA launches first diagnostic saliva test for malaria

ERADA launches first diagnostic saliva test for malaria

ERADA Technology Alliance Ltd (ERADA), pioneers of innovative, rapid diagnostic solutions for early detection of infectious diseases, have announced the imminent launch of a world first diagnostic saliva test for malaria. The saliva-based diagnostic tool, to be marketed by ERADA as a Saliva-based Malaria Asymptomatic and Asexual Rapid Test (SMAART) for subclinical infection, is set ...

For first time, researchers can measure insecticide

For first time, researchers can measure insecticide

Insecticide-infused mosquito netting is in widespread use around the world to limit the spread of mosquito-borne diseases, such as malaria. Researchers have now come up with a technique that measures how much insecticide is found on the surface of these nets -- paving the way for efforts to determine how long the nets are effective. ...

Gold-complexed ferrocenyl phosphines as potent antimalarials

Gold-complexed ferrocenyl phosphines as potent antimalarials

A team of researchers from the Singapore University of Technology and Design (SUTD) and Nanyang Technological University (NTU) have developed novel ferrocene-based molecules that impair the malaria parasite's metabolic function leading to parasite death. Despite concerted efforts for malaria elimination, this deadly disease remains a major health threat to the developing world. The causative agent ...

Baculovirus virion completely eliminates liver-stage parasites

Baculovirus virion completely eliminates liver-stage parasites

Currently, few antimalarial treatments exist that effectively kill liver-stage malaria parasites, which can lay dormant for months or years as in the case of <i>Plasmodium vivax</i>. Researchers from Kanazawa University have successfully demonstrated that administration of a baculovirus virion (BV) completely eliminates liver-stage parasites in a mouse model via BV-induced fast-acting innate immunity. Further development of ...

Researchers uncover a number of previously unknown

Researchers uncover a number of previously unknown

Researchers at LSTM have used a bioinformatics approach to integrate information from multiple studies on insecticide resistance in mosquitoes and uncovered a number of important resistance mechanisms that had not previously been recognized. In a study published in Nature Communications, Dr Victoria Ingham and colleagues have utilized specialist computer programming to better understand the mechanisms ...

New Cochrane review assesses efficacy of

New Cochrane review assesses efficacy of

Researchers from LSTM have confirmed that using pyrethroid-PBO treated nets to prevent malaria is more effective at killing mosquitoes in areas where there is a high level of resistance to pyrethroids. The distribution of nets treated with pyrethroid insecticides has been very effective in reducing malaria transmission during the past two decades in Africa. However, ...

Killing the liver-stage malaria parasite with baculovirus: a drug

Killing the liver-stage malaria parasite with baculovirus: a drug

Currently, few antimalarial treatments exist that effectively kill liver-stage malaria parasite Plasmodium vivax, which can lay dormant for months or even years. Researchers have reported a new drug that could eliminate liver-stage malaria parasites completely. Using an insect virus, known as a baculovirus, the researchers investigated the ability of baculovirus to mediate innate immunity against ...

Half a million tests and many mosquitoes later, new buzz

Half a million tests and many mosquitoes later, new buzz

Researchers spent two years testing chemical compounds for their ability to inhibit the malaria parasite at an earlier stage in its lifecycle than most current drugs, revealing a new set of chemical starting points for the first drugs to prevent malaria instead of just treating the symptoms. Most malaria drugs are designed to reduce symptoms ...