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Researchers uncover a number of previously unknown

Researchers uncover a number of previously unknown

Researchers at LSTM have used a bioinformatics approach to integrate information from multiple studies on insecticide resistance in mosquitoes and uncovered a number of important resistance mechanisms that had not previously been recognized. In a study published in Nature Communications, Dr Victoria Ingham and colleagues have utilized specialist computer programming to better understand the mechanisms ...

New Cochrane review assesses efficacy of

New Cochrane review assesses efficacy of

Researchers from LSTM have confirmed that using pyrethroid-PBO treated nets to prevent malaria is more effective at killing mosquitoes in areas where there is a high level of resistance to pyrethroids. The distribution of nets treated with pyrethroid insecticides has been very effective in reducing malaria transmission during the past two decades in Africa. However, ...

Killing the liver-stage malaria parasite with baculovirus: a drug

Killing the liver-stage malaria parasite with baculovirus: a drug

Currently, few antimalarial treatments exist that effectively kill liver-stage malaria parasite Plasmodium vivax, which can lay dormant for months or even years. Researchers have reported a new drug that could eliminate liver-stage malaria parasites completely. Using an insect virus, known as a baculovirus, the researchers investigated the ability of baculovirus to mediate innate immunity against ...

Half a million tests and many mosquitoes later, new buzz

Half a million tests and many mosquitoes later, new buzz

Researchers spent two years testing chemical compounds for their ability to inhibit the malaria parasite at an earlier stage in its lifecycle than most current drugs, revealing a new set of chemical starting points for the first drugs to prevent malaria instead of just treating the symptoms. Most malaria drugs are designed to reduce symptoms ...

Zambia trial cuts severe malaria deaths by 96 percent

Zambia trial cuts severe malaria deaths by 96 percent

A suppository form of the common antimalarial artesunate has dramatically cut child deaths from severe malaria in a trial in rural Zambia, one of the organisations behind the programme has said"] The suppository formulation was given to children who were assessed before referral to a health facility. “Knowledge of severe malaria danger signs at a community level improved ...

World Malaria Report 2018: Progress and Peril

World Malaria Report 2018: Progress and Peril

This post lays out the main takeaways from this year's World Malaria Report: Progress: Seven million lives have been saved since 2000, that’s a 60% reduction of malaria cases and deaths. The report shows that the efforts to fight malaria from countries like India, Rwanda, Ethiopia and Pakistan have been successful, the tide is turning, cases are slowly but ...

Protection against Malaria: A matter of balance

Protection against Malaria: A matter of balance

A balanced production of pro and anti-inflammatory cytokines at two years of age protects against clinical malaria in early childhood, according to a new study. The results also indicated that early exposure to the parasite does not affect the risk of developing the disease, although it could affect the parasite-specific immune response later in life. ...

Disrupting parasites’ family planning could aid malaria fight

Disrupting parasites’ family planning could aid malaria fight

Scientists investigating how the human immune system defends against malaria have uncovered a rare phenomenon: antibodies working together to bind to a vulnerable spot on the parasite. Scientists have found that the reproduction strategy used by the disease-causing parasites is more sophisticated than previously thought, and is similar to that seen in more complex organisms. ...

Fighting mosquitoes in your backyard with scientists’ help

Fighting mosquitoes in your backyard with scientists’ help

Thanks to an innovative mosquito control approach, residents in several Maryland neighborhoods reduced populations of invasive Asian tiger mosquitoes by an impressive 76 percent, on average. The Rutgers-led project, called Citizen Action through Science (Citizen AcTS), mobilizes neighbors guided by scientists to address local problems, according to a study in the journal Scientific Reports this week. This ...